Cairns is a provincial city, with a linear urban layout that runs from the south at Edmonton to the north at Ellis Beach. The city is approximately 52 km (32 mi) from north to south; it has experienced a recent urban sprawl, with suburbs occupying land once used for sugar cane farming.

The Northern Beaches consist of a number of beach communities extending north along the coast. In general, each beach suburb is at the end of a spur road extending from the Captain Cook Highway. From south to north, these are Machans Beach, Holloways Beach, Yorkeys Knob, Trinity Park, Trinity Beach, Kewarra Beach, Clifton Beach, Palm Cove, and Ellis Beach.

The suburb of Smithfield is inland against the mountains of the Great Dividing Range, between Yorkeys Knob and Trinity Park. It serves as the main hub for the Northern Beaches, with a modern shopping arcade, called Smithfield Shopping Centre.

South of Smithfield and inland from the Northern Beaches along the edge of the Barron River flood plain are the suburbs of Caravonica, Kamerunga, Freshwater, and Stratford. This area is sometimes referred to as Freshwater Valley, though it is actually the lower part of Redlynch Valley; further up the valley are the suburbs of Redlynch, on the western side of Redlynch Valley, and Brinsmead on the eastern side. Stratford, Freshwater, and Brinsmead are separated from Cairns city by Mount Whitfield (elevation 365 m (1,198 ft)) and Whitfield Range. Crystal Cascades and Copperlode Dam are also behind this range. (Kuranda, a town on the Barron River on the western side of the Macalister Range, forms part of the Cairns economic catchment but is in the Tablelands local government area and is not part of the Cairns urban area.)

The city centre of Cairns is adjacent to the suburbs of Cairns North, and Parramatta Park, Bungalow, Portsmith, and close to Westcourt, Manunda, Manoora, Edge Hill, Whitfield, Kanimbla, Mooroobool, Earlville, Woree and Bayview Heights. The small suburb of Aeroglen is pressed between Mount Whitfield and the airport, on the Captain Cook Highway between Cairns North and Stratford.

Southside Cairns, situated in a narrow area between Trinity Inlet to the east and Lamb Range to the west, includes the suburbs of White Rock, Mount Sheridan, Bentley Park and Edmonton. The townships of Goldsborough, Little Mulgrave, and Aloomba are near Gordonvale, on the Mulgrave River. This area is serviced by the Bruce Highway. Several other small towns and communities within Cairns' jurisdiction are sparsely located along the Bruce highway, the furthest being Mirriwinni, 66 km (41 mi) south of Cairns city; the largest of these townships is Babinda, about 60 km (37 mi) from the city.